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Immuno-line assay based on recombinant antigens for the determination of antibodies against Epstein-Barr Virus in human serum and plasma. One single strip allows simultaneous detection of antibodies against 5 recombinant proteins: EBNA-1p72, VCAp18, VCAp23, EAp54 et EAp138.
| - RELIABLE: |
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- Quality system certified ISO 9001 and ISO 13485.
- 5 recombinant antigens: EBNA-1 p72, VCA p18, VCA p23, EA p54 and EA p138.
- High sensitivity and specificity: > 99%.
- No interference with anticellular antibodies.
- In case of immuno suppression, approximately 5% of people do not develop anti-EBNA-1 antibodies after an EBV infection and by this pretend a primary infection.
This diagnostic gap can be filled by a second marker, the VCA antigen r-p18.
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| - FAST: |
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- Results within 2 hours (included 3 incubations).
- Easy and clear interpretation, due to easy to read bands.
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| - SIMPLE: |
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- Long shelf life: 18 months at 4OC.
- Packaging presentation: 25 tests/kit.
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| - PRACTICAL: |
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- Incubation at room temperature.
- EBVCHECK IgG & IgM strips can be used one by one, with or without automat.
- Separate detection of IgG, IgM and IgA antibodies possible.
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The diagnosis of an EBV primary infection is often made by means of heterophilic antibodies detection (MNI test and Paul Bunnel Davidsohn reaction).
The serological EBV diagnosis has 2 advantages compared to the MNI test:
- it gives the exact serological diagnosis (past infection recent infection, seronegative, reactivation),
- it completes the detection of the heterophilic antibodies that are not present in 30% of children primary infection.
- Over 95% of adults are seropositive and are virus carriers, since EBV persists throughout lifetime in lymphocytes B and in certain epithelium cells. - After the primary infection, EBV remains for the lifetime in lymphocytes B and epithelia of the nose and throat. When transmitted in saliva, EBV leads to infant infections which are however often asymptomatic or sub-clinical. For young people between 14 and 20 years of age there is a second peak of contagion. In 2/3 of the cases the infectious mononucleosis can develop.
The serological EBV diagnosis is based on the detection of specific antibodies. The profile of appearance of these antibodies allows to determine the different stages of the EBV infection (see the anti-EBV kinetic).
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